Dr. Jonathan M. Wright

PROFESSOR
BSc Honours (Mt. Allison)
PhD (Memorial)

  • Teaching & Research
  • Students' Research Topics
  • Graduates' occupations
  • Publications
  • Links   
  • Teaching & Research
    Mechanisms and evolution of gene regulation, gene structure and function, zebrafish, development, fatty acid and retinoid binding proteins.

    Desearch interests of my laboratory include:

    Classes in which Jonathan currently teaches:
    • (I) Expression of genes coding for fatty acid and retinoid (vitamin A derivatives) binding proteins in adults and embryos of the zebrafish. Zebrafish serves as a model system for vertebrate development as many of the genes and the developmental processes they control are similar, or the same, in zebrafish and humans. As such, studies in zebrafish can provide valuable insights into developmental processes and disease of humans.
    • (II) Localization of cloned genes to fish chromosomes to determine the structure and evolution of chromosomes.
      Examples of Students' Research Topics
    Honours BSc Students
    • Joshua Lee. 2013. Duplicated crabp1 and crabp2 genes in medaka (Oryzias latipes): gene structure, phylogenetic relationship and tissue-specific distribution of transcripts.
    • Daniel Belliveau. 2010. Duplicated rbp7 genes are differentially transcribed in embryos and adult Zebrafish.
    • Daniel Sawler. 2008. Regulation of the fabp3 gene by fatty acids and clofribrate in zebrafish.
    • Mark Soric. 2007. The genesis and fate of the duplicated fabp4 genes of zebrafish.
    • Sherri Powell. 2003. Expression of retinoid x receptor genes in zebrafish.
    • Amy Harris. 2002. Expression of the CRBP II gene in zebrafish.
    • Kevin Alban. 2001. Population genetics of the Blanding's turtle using mitochondrial DNA sequences.
    • Vivian Anopuechi. 2001. Expression of a cellular retinol (vitamin A) binding protein gene during zebrafish embryogenesis.
    • Marianne Cameron. 2001. Sequence and tissue-specific expression of a cellular retinol binding protein gene in adult zebrafish.
    • Marianne Pierce. 1999. Tissue-specific expression of an intestinal-type fatty acid binding protein gene in zebrafish.
    • Julie Labbé. 1998. Localization of the 5S ribosomal RNA genes to metaphase chromosomes of Oreochromis niloticus by fluorescent in situ hybridization.
    Silver grains in emulsion autoriography indicates the gene transcripts for a brain fatty acid binding protein in zebrafish.
    Detection of telomeres (chromosome ends) in the chromosomes of the
    African cichlid fish, tilapia.

    Graduate Students

    • Aruloli Thurmaran. 2013. The fatty acid-binding protein (fabp) genes of spotted green pufferfish (Tetroaodon nigroviridis) – A comparative structural genomics and tissue-specific distribution of transcripts.
    • Ananda B. Venkatachalam. 2012. Induction of fatty acid-binding protein genes by clofibrate in zebrafish.
    • Manoj Parmar. 2011. The multigene family of fatty acid-binding protein gens in medaka (Oryzias latipes).
    • Santosh Karanth. 2010. Dietary fatty acids differentially induce the transcription of duplicated fatty acid-binding protein genes in zebrafish.
    • Fermanda Alves-Costa. 2007. Spatio-temporal distribution of fatty acid-binding protein 6 (fabp6) gene transcripts in zebrafish (visiting student from Brazil)
    • Qian Sun. 2005. Functional promotor analysis of three intracellular lipid-binding protein genes from zebrafish (Danio reiro).
    • Vishal Saxena. 2005. Functional promoter analysis of four intracellular lipid-binding protein genes in zebrafish. .
    • Mukesh Sharma. 2005. Regulation of the genes for the intestinal- and liver-type fatty acid binding proteins in embryos and adults of zebrafish.
    • Rongzong Liu. 2005. Regulation of the genes for the brain and heart-type fatty acid binding proteins in embryos and adults of zebrafish.
    • Steve Mockford. 2005. Behavioural and population genetics of Blanding's turtle.
    • Cinthia Bachir. 2001. Systematics and population structure of Brazilian fishes. (visiting student from the University of São Paulo).
    Jonathan's Lab Staff

    Some Graduates' Occupations
    • Postdoctoral Fellows, Universities of Alberta, Utah, Washington and Brazil (UNESP-São Paulo)
    • Research Technicians, Universities of Ottawa, Dalhousie and Guelph.  
    • High/Grammar School Teacher, Wales, Australia and Canada.  
    • Medical and Dentistry School, Grenada and Canada.
    • Ph.D. Studies, Canada, South Africa and New Zealand. 
    • Dentistry student.
    • Professors, Universities of Sheffield (UK), Alberta, British Columbia and Winnipeg
    • Government Fisheries scientist, Canada.
    • Systems analyst.
    • Psychiatrist.

     


    Selected Publications

    Comparative genomic organization and tissue-specific transcription of the duplicated fabp7 and fabp10 genes in teleost fishes.
    Parmar MB, Wright JM.
    Genome. 2013 Nov;56(11):691-701. doi: 10.1139/gen-2013-0172. Epub 2013 Nov 1. PMID:24299108

    Genomic organization and transcription of the medaka and zebrafish cellular retinol-binding protein (rbp) genes.
    Parmar MB, Shams R, Wright JM.
    Mar Genomics. 2013 Sep;11:1-10. doi: 10.1016/j.margen.2013.04.001. Epub 2013 Apr 28. PMID:23632098

    Tissue-specific transcriptional modulation of fatty acid-binding protein genes, fabp2, fabp3 and fabp6, by fatty acids and the peroxisome proliferator, clofibrate, in zebrafish (Danio rerio).
    Venkatachalam AB, Sawler DL, Wright JM.
    Gene. 2013 May 10;520(1):14-21. doi: 10.1016/j.gene.2013.02.034. Epub 2013 Mar 4. PMID:23466978

    Duplicated crabp1 and crabp2 genes in medaka (Oryzias latipes): gene structure, phylogenetic relationship and tissue-specific distribution of transcripts.
    Parmar MB, Lee JJ, Wright JM.
    Comp Biochem Physiol B Biochem Mol Biol. 2013 May;165(1):10-8. doi: 10.1016/j.cbpb.2013.02.006. Epub 2013 Feb 28. PMID:23458901

    Comparative evolutionary genomics of medaka and three-spined stickleback fabp2a and fabp2b genes with fabp2 of zebrafish.
    Parmar MB, Wright JM.
    Genome. 2013 Jan;56(1):27-37. doi: 10.1139/gen-2012-0140. Epub 2013 Jan 1. PMID:23379336

    Comparative genomics and evolutionary diversification of the duplicated fabp6a and fabp6b genes in medaka and three-spined stickleback.
    Parmar MB, Venkatachalam AB, Wright JM.
    Comp Biochem Physiol Part D Genomics Proteomics. 2012 Dec;7(4):311-21. doi: 10.1016/j.cbd.2012.10.001. Epub 2012 Oct 10. PMID:23123309

    The evolutionary relationship of the transcriptionally active fabp11a (intronless) and fabp11b genes of medaka with fabp11 genes of other teleost fishes.
    Parmar MB, Venkatachalam AB, Wright JM.
    FEBS J. 2012 Jul;279(13):2310-21. doi: 10.1111/j.1742-4658.2012.08611.x. Epub 2012 May 21. PMID:22520026

    Tissue-specific differential induction of duplicated fatty acid-binding protein genes by the peroxisome proliferator, clofibrate, in zebrafish (Danio rerio).
    Venkatachalam AB, Lall SP, Denovan-Wright EM, Wright JM.
    BMC Evol Biol. 2012 Jul 9;12:112. doi: 10.1186/1471-2148-12-112. PMID:22776158

    The duplicated retinol-binding protein 7 (rbp7) genes are differentially transcribed in embryos and adult zebrafish (Danio rerio).
    Belliveau DJ, Venkatachalam AB, Thisse C, Thisse B, Ma H, Wright JM.
    Gene Expr Patterns. 2010 Jun;10(4-5):167-76. doi: 10.1016/j.gep.2010.04.003. Epub 2010 Apr 14. PMID:20398800

    Differential tissue-specific distribution of transcripts for the duplicated fatty acid-binding protein 10 (fabp10) genes in embryos, larvae and adult zebrafish (Danio rerio).
    Venkatachalam AB, Thisse C, Thisse B, Wright JM.
    FEBS J. 2009 Nov;276(22):6787-97. doi: 10.1111/j.1742-4658.2009.07393.x. Epub 2009 Oct 16. PMID:19843178

    Tandem duplication of the fabp1b gene and subsequent divergence of the tissue-specific distribution of fabp1b.1 and fabp1b.2 transcripts in zebrafish (Danio rerio).
    Karanth S, Denovan-Wright EM, Thisse C, Thisse B, Wright JM.
    Genome. 2009 Dec;52(12):985-92. doi: 10.1139/G09-071. PMID:19953126

    Differential transcriptional modulation of duplicated fatty acid-binding protein genes by dietary fatty acids in zebrafish (Danio rerio): evidence for subfunctionalization or neofunctionalization of duplicated genes.
    Karanth S, Lall SP, Denovan-Wright EM, Wright JM.
    BMC Evol Biol. 2009 Sep 2;9:219. doi: 10.1186/1471-2148-9-219. PMID:19725974

    Spatio-temporal distribution of fatty acid-binding protein 6 (fabp6) gene transcripts in the developing and adult zebrafish (Danio rerio).
    Alves-Costa FA, Denovan-Wright EM, Thisse C, Thisse B, Wright JM.
    FEBS J. 2008 Jul;275(13):3325-34. doi: 10.1111/j.1742-4658.2008.06480.x. Epub 2008 May 19. PMID:18492067

    The evolutionary relationship between the duplicated copies of the zebrafish fabp11 gene and the tetrapod FABP4, FABP5, FABP8 and FABP9 genes.
    Karanth S, Denovan-Wright EM, Thisse C, Thisse B, Wright JM.
    FEBS J. 2008 Jun;275(12):3031-40. doi: 10.1111/j.1742-4658.2008.06455.x. Epub 2008 Apr 26. PMID:18445037

     

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